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Biblioteca (s) : |
INIA Tacuarembó. |
Fecha : |
01/09/2020 |
Actualizado : |
01/09/2020 |
Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
Autor : |
MACHADO, M.; CASTRO, M.B; GIMENO, E.J.; BARROS, S.S.; RIET-CORREA, F. |
Afiliación : |
MIZAEL MACHADO DA COSTA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; MARCIO B. CASTRO, Laboratorio de Patologia Veterinaria, Universidade de Brasília, Brasília, Brazil; EDUARDO J. GIMENO, Faculdad de Ciencias Veterinarias, National University of La Plata, Argentina; SEVERO S. BARROS, Laboratorio de Patologia Veterinaria, Universidade Federal de Santa Maria, Santa Maria, Rio Grande do Sul, Brazil; FRANKLIN RIET-CORREA AMARAL, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
Título : |
Enzootic calcinosis in ruminants: A review. |
Fecha de publicación : |
2020 |
Fuente / Imprenta : |
Toxicon, 2020, volumen 187, Pages 1-9. Doi: https://doi.org/10.1016/j.toxicon.2020.08.009 |
DOI : |
10.1016/j.toxicon.2020.08.009 |
Idioma : |
Inglés |
Contenido : |
ABSTRACT: Enzootic calcinosis (EC), is a chronic disease, caused by toxic plants, which has mainly affected ruminants for more than 100 years. It is characterized by a soft tissue calcification, hypercalcemia, hyperphosphatemia, hypoparathiroidism, hypercalcitoninism, osteonecrosis, and osteopetrosis. The toxic compound reported in some of these plants are 1,25(OH)2D3 glycosides. Characterization of calcinogenic principles were performed with Solanum glaucophyllum, Trisetum flavescens, Cestrum diurnum, and Stenotaphrum secundatum. Other plant species involved in EC are: Nierembergia rivularis, Nierembergia veitchii, Solanum torvum, and Solanum stuckertii. Clinical and pathological findings are well characterized. We present different aspects of the pathogenic mechanism of EC, including genetic modulation, expression of bone proteins, cellular de-differentiation of arterial smooth muscle cells, phenotypic changes, production of a calcifiable matrix, and modulation of the calcium and phosphorus balance. The use of comparative pathology can bring significant advances in the understanding of the pathogenic mechanism. In this review we present a broad approach to the different aspects of intoxication: history of EC on different continents; plant species, distribution and morphology; toxic principle; pathogenesis; epidemiology; clinical signs; diagnosis; and control and prophylaxis. |
Palabras claves : |
CALCINOGENIC PLANTS; CALCINOSIS ENZOÓTICA; ENZOOTIC CALCINOSIS; INTOXICACIÓN; PATHOGENESIS; PLANTAS TÓXICAS; RUMIANTES; VITAMIN D; VITAMINA D. |
Asunto categoría : |
L01 Ganadería |
Marc : |
LEADER 02226naa a2200289 a 4500 001 1061290 005 2020-09-01 008 2020 bl uuuu u00u1 u #d 024 7 $a10.1016/j.toxicon.2020.08.009$2DOI 100 1 $aMACHADO, M. 245 $aEnzootic calcinosis in ruminants$bA review.$h[electronic resource] 260 $c2020 520 $aABSTRACT: Enzootic calcinosis (EC), is a chronic disease, caused by toxic plants, which has mainly affected ruminants for more than 100 years. It is characterized by a soft tissue calcification, hypercalcemia, hyperphosphatemia, hypoparathiroidism, hypercalcitoninism, osteonecrosis, and osteopetrosis. The toxic compound reported in some of these plants are 1,25(OH)2D3 glycosides. Characterization of calcinogenic principles were performed with Solanum glaucophyllum, Trisetum flavescens, Cestrum diurnum, and Stenotaphrum secundatum. Other plant species involved in EC are: Nierembergia rivularis, Nierembergia veitchii, Solanum torvum, and Solanum stuckertii. Clinical and pathological findings are well characterized. We present different aspects of the pathogenic mechanism of EC, including genetic modulation, expression of bone proteins, cellular de-differentiation of arterial smooth muscle cells, phenotypic changes, production of a calcifiable matrix, and modulation of the calcium and phosphorus balance. The use of comparative pathology can bring significant advances in the understanding of the pathogenic mechanism. In this review we present a broad approach to the different aspects of intoxication: history of EC on different continents; plant species, distribution and morphology; toxic principle; pathogenesis; epidemiology; clinical signs; diagnosis; and control and prophylaxis. 653 $aCALCINOGENIC PLANTS 653 $aCALCINOSIS ENZOÓTICA 653 $aENZOOTIC CALCINOSIS 653 $aINTOXICACIÓN 653 $aPATHOGENESIS 653 $aPLANTAS TÓXICAS 653 $aRUMIANTES 653 $aVITAMIN D 653 $aVITAMINA D 700 1 $aCASTRO, M.B 700 1 $aGIMENO, E.J. 700 1 $aBARROS, S.S. 700 1 $aRIET-CORREA, F. 773 $tToxicon, 2020, volumen 187, Pages 1-9. Doi: https://doi.org/10.1016/j.toxicon.2020.08.009
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INIA Tacuarembó (TBO) |
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Biblioteca (s) : |
INIA Treinta y Tres. |
Fecha actual : |
17/04/2017 |
Actualizado : |
11/10/2019 |
Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
Circulación / Nivel : |
A - A |
Autor : |
LAKIN, S.M.; DEAN, C.; NOYES, N.R.; DETTENWANGER, A.; ROSS, A. S.; DOSTER, E.; ROVIRA, P.J.; ABDO, Z.; JONES, K.L.; RUIZ, J.; BELK, K.E.; MORLEY, P.S.; BOUCHER, C. |
Afiliación : |
STEVEN M. LAKIN; CHRIS DEAN; NOELLE R. NOYES; ADAM DETTENWANGER; ANNE SPENCER ROSS; ENRIQUE DOSTER; PABLO JUAN ROVIRA SANZ, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. Department of Animal Sciences, Colorado State University, USA.; ZAID ABDO; KENNETH L. JONES; JAIME RUIZ; KEITH E. BELK; PAUL S. MORLEY; CHRISTINA BOUCHER. |
Título : |
MEGARes: an antimicrobial resistance database for high throughput sequencing. |
Fecha de publicación : |
2017 |
Fuente / Imprenta : |
Nucleic Acids Research, 2017 v.45 p.574-580. |
DOI : |
10.1093/nar/gkw1009 |
Idioma : |
Inglés |
Notas : |
Article History: Published online 2016 Nov 24.
DOI: https://doi.org/10.1093/nar/gkw1009 |
Contenido : |
Antimicrobial resistance has become an imminent concern for public health. As methods for detection and characterization of antimicrobial resistance move from targeted culture and polymerase chain reaction to high throughput metagenomics, appropriate resources for the analysis of large-scale data are required. Currently, antimicrobial resistance databases are tailored to smaller-scale, functional profiling of genes using highly descriptive annotations. Such characteristics do not facilitate the analysis of large-scale, ecological sequence datasets such as those produced with the use of metagenomics for surveillance. In order to overcome these limitations, we present MEGARes (https://megares.meglab.org), a hand-curated antimicrobial resistance database and annotation structure that provides a foundation for the development of high throughput acyclical classifiers and hierarchical statistical analysis of big data. MEGARes can be browsed as a stand-alone resource through the website or can be easily integrated into sequence analysis pipelines through download. Also via the website, we provide documentation for AmrPlusPlus, a user-friendly Galaxy pipeline for the analysis of high throughput sequencing data that is pre-packaged for use with the MEGARes database. |
Palabras claves : |
BASE DE DATOS; BIOINFORMÁTICA; DATASETS; DRUG RESISTANCE; GENES; METAGENÓMICA; METAGENOMICS; MICROBIAL; POLYMERASE CHAIN REACTION; PUBLIC HEALTH MEDICINE; RESISTENCIA ANTIMICROBIANA; SEQUENCE ANALYSIS. |
Asunto categoría : |
L01 Ganadería |
URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/6677/1/Rovira-arb-2017-1.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210519/
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Marc : |
LEADER 02505naa a2200433 a 4500 001 1057051 005 2019-10-11 008 2017 bl uuuu u00u1 u #d 024 7 $a10.1093/nar/gkw1009$2DOI 100 1 $aLAKIN, S.M. 245 $aMEGARes$ban antimicrobial resistance database for high throughput sequencing.$h[electronic resource] 260 $c2017 500 $aArticle History: Published online 2016 Nov 24. DOI: https://doi.org/10.1093/nar/gkw1009 520 $aAntimicrobial resistance has become an imminent concern for public health. As methods for detection and characterization of antimicrobial resistance move from targeted culture and polymerase chain reaction to high throughput metagenomics, appropriate resources for the analysis of large-scale data are required. Currently, antimicrobial resistance databases are tailored to smaller-scale, functional profiling of genes using highly descriptive annotations. Such characteristics do not facilitate the analysis of large-scale, ecological sequence datasets such as those produced with the use of metagenomics for surveillance. In order to overcome these limitations, we present MEGARes (https://megares.meglab.org), a hand-curated antimicrobial resistance database and annotation structure that provides a foundation for the development of high throughput acyclical classifiers and hierarchical statistical analysis of big data. MEGARes can be browsed as a stand-alone resource through the website or can be easily integrated into sequence analysis pipelines through download. Also via the website, we provide documentation for AmrPlusPlus, a user-friendly Galaxy pipeline for the analysis of high throughput sequencing data that is pre-packaged for use with the MEGARes database. 653 $aBASE DE DATOS 653 $aBIOINFORMÁTICA 653 $aDATASETS 653 $aDRUG RESISTANCE 653 $aGENES 653 $aMETAGENÓMICA 653 $aMETAGENOMICS 653 $aMICROBIAL 653 $aPOLYMERASE CHAIN REACTION 653 $aPUBLIC HEALTH MEDICINE 653 $aRESISTENCIA ANTIMICROBIANA 653 $aSEQUENCE ANALYSIS 700 1 $aDEAN, C. 700 1 $aNOYES, N.R. 700 1 $aDETTENWANGER, A. 700 1 $aROSS, A. S. 700 1 $aDOSTER, E. 700 1 $aROVIRA, P.J. 700 1 $aABDO, Z. 700 1 $aJONES, K.L. 700 1 $aRUIZ, J. 700 1 $aBELK, K.E. 700 1 $aMORLEY, P.S. 700 1 $aBOUCHER, C. 773 $tNucleic Acids Research, 2017$gv.45 p.574-580.
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